As of December 2020 there is some concern that PEG could trigger allergic reaction, and in fact allergic reactions are the driver for both the United Kingdom and Canadian regulators to issue an advisory, noting that: two "individuals in the U.K.
In both vaccines, the bubbles are coated with a stabilizing molecule of polyethylene glycol. Proprietary lipid technology is used for each. Both RNA vaccines consist of messenger RNA, or mRNA, encased in a bubble of oily molecules called lipids. A PEGylated lipid is used as an excipient in both the Moderna and Pfizer–BioNTech vaccines for SARS-CoV-2.PEGylation of adenoviruses for gene therapy can help prevent adverse reactions due to pre-existing adenovirus immunity.The gel and encapsulated stem cells was to be injected to the site of disease and crosslinked to create the microenvironment required for the stem cells to function. They propose using the hydrogel to address periodontitis (gum disease) by encapsulating stem cells in the gel that promote healing in the gums. An example of PEG hydrogels (see Biological uses section) in a therapeutic has been theorized by Ma et al.The possibility that PEG could be used to fuse axons is being explored by researchers studying peripheral nerve and spinal cord injury.When attached to various protein medications or drug carriers, polyethylene glycol of suitable length slows down their clearance from the blood.PEG is used in medicines for treating disimpaction and maintenance therapy for children with constipation.Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy. PEG is the basis of a number of laxatives (as MiraLax).Pharmaceutical-grade PEG is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms.Because of our high mortality rate (82%), the consideration of antimold prophylaxis for such patients may be warranted. The significant risk factors for mold infection were total-body irradiation and grade 2-4 acute GVHD.
Overall, of the 21 patients with mold infection, 17 (81%) had invasive mold disease, and four (19%) had mold colonization of airways secondary to chronic GVHD after day 100. A stage-specific manifestation of mold infection was observed: 67% of mold infections occurred during acute graft-vs.-host disease (GVHD) a median of 47 days after transplantation, whereas 9% of mold infections occurred as rapidly fatal invasive disease before engraftment. Concentrated smears of the remaining 63 fungal culture-positive specimens were negative the strains identified by culture were considered as exogenous contaminants (87% of which were Penicillium species). Concentrated smears of only 86 (from 21 infected patients) of 149 fungal culture-positive specimens were positive for hyphae 82 of the strains were Aspergillus species. This method was applied in the study of 3,857 clinical specimens from 230 bone marrow transplant recipients who were followed up prospectively for infectious complications. Potassium hydroxide-concentrated smears, prepared from sedimented remains of clinical specimens, were used to distinguish between mold infection and exogenous contamination in fungal culture-positive specimens.
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